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TNP 470

Cat. No. 3750 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3750 has been discontinued.

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说明： Methionine aminopeptidase-2 inhibitor; antiangiogenic
别名： AGM 1470
化学名： N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
纯度： ≥97% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TNP 470

Analog of Fumagillin (Cat. No. 1768) that displays potent antiangiogenic activity in vitro and in vivo. Inhibits methionine aminopeptidase type II (MetAP2). Potently inhibits the proliferation of endothelial cells.

技术数据 for TNP 470

分子量 401.88
公式 C19H28CINO6
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 129298-91-5
Smiles [H][C@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@H](OC)[C@H](OC(NC(CCl)=O)=O)CC[C@@]21CO2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TNP 470

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参考文献 for TNP 470

参考文献是支持产品生物活性的出版物。

Arico-Muendel et al (2009) Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2. J.Med.Chem. 52 8047 PMID: 19929003

Huang et al (2003) TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol.Cancer Ther. 3 335

Miura et al (2004) Carcinosarcoma-induced endothelial cells tube formation through KDR/FLK-1 is blocked by TNP-470. Cancer Letts. 203 45

Hines et al (2010) Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. J.Pharm.Exp.Ther. 334 729

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关键词: TNP 470, TNP 470 supplier, TNP470, methionine, aminopeptidase-2, MetAP2, proteases, proteinases, antiangiogenics, angiogenesis, AGM1470, AGM, 1470, Aminopeptidases, Antiangiogenics, 3750, Tocris Bioscience

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