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Toyocamycin

Cat. No. 5270 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Adenosine analog; antifungal antibiotic
化学名： 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Toyocamycin

Toyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.

化合物库 for Toyocamycin

Toyocamycin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Toyocamycin

分子量 291.26
公式 C12H13N5O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 606-58-6
PubChem ID 12444444
InChI Key XOKJUSAYZUAMGJ-NNXMZFEESA-N
Smiles NC1=C2C(N([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)C=C2C#N)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Toyocamycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.13 100

制备储备液 for Toyocamycin

以下数据基于产品分子量 291.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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产品说明书 for Toyocamycin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Toyocamycin

参考文献是支持产品生物活性的出版物。

Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79 PMID: 22852048

Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586 PMID: 2177464

Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797 PMID: 16556935

If you know of a relevant reference for Toyocamycin, please let us know.

按标靶查看相关产品

关键词: Toyocamycin, Toyocamycin supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Antibiotics, Antifungals, 5270, Tocris Bioscience

1 篇 Toyocamycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Toyocamycin 的部分引用包括：

Tanabe et al (2018) IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. Oncotarget 9 14428 PMID: 29581854

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Toyocamycin 的评论

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The pathway of inhibition of auxin-responsive gene expression by Toyocamycin was studied.
By Josh McKay on 02/18/2019
种属： Human

The pathway of inhibition of auxin-responsive gene expression by Toyocamycin was studied. Solutions prepared in DMSO can be diluted 20-fold in water.

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