TR 14035

Cat. No. 6908 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent integrin α₄β₇ and α₄β₁ (VLA-4) antagonist; orally bioavailable

化学名： (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TR 14035

TR 14035 is a potent integrin α₄β₇ and α₄β₁ antagonist (IC₅₀ values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.

化合物库 for TR 14035

TR 14035 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TR 14035

分子量	474.33
公式	C₂₄H₂₁Cl₂NO₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	232271-19-1
PubChem ID	9912743
InChI Key	DRSJLVGDSNWQBI-SFHVURJKSA-N
Smiles	COC1=CC=CC(OC)=C1C1=CC=C(C[C@H](NC(=O)C2=C(Cl)C=CC=C2Cl)C(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TR 14035

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	47.43	100
	ethanol	9.49	20

制备储备液 for TR 14035

以下数据基于产品分子量 474.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for TR 14035

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TR 14035

参考文献是支持产品生物活性的出版物。

Sircar et al (2002) Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α₄β₇/α₄β₁ integrin antagonist. Bioorg.Med.Chem. 6 20151 PMID: 11937364

Jürets et al (2019) Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage. PLoS One 11 e0148333 PMID: 26840958

If you know of a relevant reference for TR 14035, please let us know.

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关键词: TR 14035, TR 14035 supplier, TR14035, potent, integrin, antagonist, alpha4beta1, alpha4beta7, alfa4, a4b1, a4b7, β, α, orally, bioavailable, Integrins, 6908, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.