trans-Ned 19

Cat. No. 3954 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： NAADP antagonist; inhibits Ca²⁺ release

化学名： (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

纯度： ≥98% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for trans-Ned 19

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca²⁺ release (IC₅₀ = 6 nM); also inhibits [³²P]NAADP binding (IC₅₀ = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).

Optical Data for trans-Ned 19

λ_abs	368 nm
λ_em	425 nm
Closest Laser line	355 nm
Cell Permeable	Yes
Application	Confocal Microscopy

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技术数据 for trans-Ned 19

分子量	514.59
公式	C₃₀H₃₁FN₄O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1354235-96-3
PubChem ID	1427628
InChI Key	FUHCEERDBRGPQZ-LBNVMWSVSA-N
Smiles	FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H](C(O)=O)N3)=CC=C2OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for trans-Ned 19

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	51.46	100

制备储备液 for trans-Ned 19

以下数据基于产品分子量 514.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.72 mL	19.43 mL
5 mM	0.39 mL	1.94 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for trans-Ned 19

分析证书/产品说明书

化学品安全技术说明书

参考文献 for trans-Ned 19

参考文献是支持产品生物活性的出版物。

Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220 PMID: 19234453

Rosen et al (2009) Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J.Biol.Chem. 284 34930 PMID: 19826006

Thai et al (2009) NAADP receptors mediate calcium signaling stimulated by endothelin-1 and NE in renal afferent arterioles. Am.J.Physiol.Renal Physiol. 297 F510 PMID: 19439521

If you know of a relevant reference for trans-Ned 19, please let us know.

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关键词: trans-Ned 19, trans-Ned 19 supplier, NAAPD, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, ned19, General, Calcium, Signaling, Agents, 3954, Tocris Bioscience