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Submit ReviewTrazodone hydrochloride
说明： 5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
化学名： 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Trazodone hydrochloride
Trazodone hydrochloride is a 5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.
化合物库 for Trazodone hydrochloride
Trazodone hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Trazodone hydrochloride
| 分子量 | 408.32 |
| 公式 | C19H22ClN5O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 25332-39-2 |
| PubChem ID | 62935 |
| InChI Key | OHHDIOKRWWOXMT-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(N2CCN(CC2)CCCN3N=C4C=CC=CN4C3=O)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Trazodone hydrochloride
参考文献 for Trazodone hydrochloride
参考文献是支持产品生物活性的出版物。
Bortolotto et al (2017) Proneurogenic effects of traz. in murine and human neural progenitor cells. ACS Chem.Neurosci. 8 2027 PMID: 28636360
Halliday et al (2017) Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 140 1768 PMID: 28430857
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关键词: Trazodone hydrochloride, Trazodone hydrochloride supplier, 5-HT2A, alpha1, a1, α1, adrenoceptor, antagonist, antagonism, neuronal, differentiation, antidepressant, depression, neuroprotection, neuroprotectant, eIF2alpha, eIF2a, eIF2α, inhibitors, inhibits, Receptors, Adrenergic, Alpha-1, Neural, Stem, Cells, PERK, 6336, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.