Trequinsin hydrochloride

Cat. No. 2337 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent PDE3 inhibitor

别名： HL-725

化学名： 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

纯度： ≥97% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Trequinsin hydrochloride

Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC₅₀ = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC₅₀ = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca²⁺ and cGMP levels, and decreases potassium channel activity in sperm.

化合物库 for Trequinsin hydrochloride

Trequinsin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Trequinsin hydrochloride

分子量	441.95
公式	C₂₄H₂₇N₃O₃.HCl
储存	Desiccate at RT
纯度	≥97% (HPLC)
CAS Number	78416-81-6
PubChem ID	3060974
InChI Key	DTCZZBVPTHVXFA-UHFFFAOYSA-N
Smiles	Cl.COC1=C(OC)C=C2C(CCN3C(=O)N(C)C(\C=C23)=N\C2=C(C)C=C(C)C=C2C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Trequinsin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.2	100
	ethanol	44.2	100

制备储备液 for Trequinsin hydrochloride

以下数据基于产品分子量 441.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.31 mL	22.63 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for Trequinsin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Trequinsin hydrochloride

参考文献是支持产品生物活性的出版物。

et al (1984) Trequinsin, J.Med.Chem. 1470 et al (2019) Novel pharmacological Br.J.Pharmacol.

If light">Ruppert and Weithmann an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. 31 PMID: 6294426

light">Lal a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones. 27 PMID: 6492077

light">Agarwal plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. 47 PMID: 2821650

light">McBrinn actions of Trequinsin Hydrochloride improve human sperm cell motility and function. PMID: 31368510 you know of a relevant reference for Trequinsin hydrochloride, please let us know.

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1 篇 Trequinsin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Trequinsin hydrochloride 的部分引用包括：

McBrinn et al (2019) Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br.J.Pharmacol. 176 4521 PMID: 31368510

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