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Troglitazone

Cat. No. 3114 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective PPARγ agonist; antidiabetic agent
别名： Rezulin
化学名： 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Troglitazone

Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

化合物库 for Troglitazone

Troglitazone is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Troglitazone

分子量 441.54
公式 C24H27NO5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 97322-87-7
PubChem ID 5591
InChI Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Smiles CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Troglitazone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.15 100

制备储备液 for Troglitazone

以下数据基于产品分子量 441.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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产品说明书 for Troglitazone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Troglitazone

参考文献是支持产品生物活性的出版物。

Lee and Olefsky (1995) Acute effects of troglitazone on in vivo Ins action in normal rats. Metabolism 44 1166 PMID: 7666790

Kodera et al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201 PMID: 10944516

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680

Fujimura et al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263 PMID: 9824642

If you know of a relevant reference for Troglitazone, please let us know.

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关键词: Troglitazone, Troglitazone supplier, Selective, PPARγ, PPARgamma, agonists, antidiabetic, agent, Peroxisome, Proliferator-activating, Receptors, hematopoietic, haematopoietic, stem, cells, HSC, Rezulin, Stem, Cell, Proliferation, Hematopoietic, Cells, 3114, Tocris Bioscience

3 篇 Troglitazone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Troglitazone 的部分引用包括：

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

Ross et al (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and sora. Cell Chem Biol 24 813 PMID: 28625738

Hegde et al (2015) Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo. J Immunol 194 5211 PMID: 25917103

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