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Trolox

Cat. No. 6002 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
化学名： 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Trolox

Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.

技术数据 for Trolox

分子量 250.29
公式 C14H18O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 53188-07-1
PubChem ID 40634
InChI Key GLEVLJDDWXEYCO-UHFFFAOYSA-N
Smiles CC1=C(C(C)=C2CCC(OC2=C1C)(C(O)=O)C)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Trolox

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.03 100
ethanol 25.03 100

制备储备液 for Trolox

以下数据基于产品分子量 250.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4 mL 19.98 mL 39.95 mL
5 mM 0.8 mL 4 mL 7.99 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Trolox

参考文献是支持产品生物活性的出版物。

Giulivi et al (1993) Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 303 152 PMID: 8489259

Lee et al (2009) Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 284 13725 PMID: 19299513

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443

Cordes et al (2009) On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc. 131 5018 PMID: 19301868

If you know of a relevant reference for Trolox, please let us know.

按标靶查看相关产品

关键词: Trolox, Trolox supplier, Antioxidant, vitamin, E, derivatives, osteoclast, formation, loss, bone, antifade, reagents, live, cell, imaging, blinking, photobleaching, hematopoietic, haematopoietic, stem, cells, HSC, Antioxidants, Ferroptosis, Antifade, Reagents, Hematopoietic, Stem, Cells, 6002, Tocris Bioscience

2 篇 Trolox 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Trolox 的部分引用包括：

Miriam et al (2020) Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep 30 3250-3260.e7 PMID: 32160534

Yi-Sook et al (2020) Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity. Antioxidants (Basel) 9 PMID: 32916895

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该领域的文献

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