Tropisetron hydrochloride

Cat. No. 2459 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent 5-HT₃ antagonist; also α7 nAChR partial agonist

别名： Novaban,ICS 205930

化学名： (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride

纯度： ≥99% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tropisetron hydrochloride

Tropisetron hydrochloride is a potent, orally active 5-HT₃ receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7^Q79G-GlyR chimeric ion channels (EC₅₀ = 38 nM)

技术数据 for Tropisetron hydrochloride

分子量	320.82
公式	C₁₇H₂₀N₂O₂.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	105826-92-4
PubChem ID	656664
InChI Key	XIEGSJAEZIGKSA-KOQCZNHOSA-N
Smiles	O=C(O[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)C2=CNC1=CC=CC=C12.O=C(O[C@@H]7C[C@H]8CC[C@H](N8C)C7)C6=CNC5=CC=CC=C56.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tropisetron hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	32.08	100
	DMSO	16.04	50

制备储备液 for Tropisetron hydrochloride

以下数据基于产品分子量 320.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.59 mL	31.17 mL
5 mM	0.62 mL	3.12 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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产品说明书 for Tropisetron hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tropisetron hydrochloride

参考文献是支持产品生物活性的出版物。

Seynaeve et al (1991) 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron. Anticancer Drugs 2 343 PMID: 1665723

Middlemiss and Tricklebank (1992) Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 16 75 PMID: 1553108

Mhatre et al (2004) 5-HT₃ antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 491 149 PMID: 15140631

Papke et al (2004) Activity of α7-selective agonists at nicotinic and serotonin 5HT₃ receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 14 1849 PMID: 15050614

If you know of a relevant reference for Tropisetron hydrochloride, please let us know.

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关键词: Tropisetron hydrochloride, Tropisetron hydrochloride supplier, Potent, 5-HT3, receptor, antagonists, orally, active, Serotonin, Receptors, ICS205930, Nicotinics, nAChRs, alpha7, a7, α7, partial, agonists, chemogenetics, Navoban, ICS, 205930, Nicotinic, (a7), PSEMs, 2459, Tocris Bioscience

4 篇 Tropisetron hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tropisetron hydrochloride 的部分引用包括：

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Respir Physiol Neurobiol 7 2336 PMID: 26114334

Johnson et al (2015) Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Proc Natl Acad Sci U S A 207 48 PMID: 25543027

Spilman et al (2014) The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res 1551 25 PMID: 24389031

Sendin et al (2014) Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Mol Cell Biol 111 1999 PMID: 24429348

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