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Tucatinib

Cat. No. 7640 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective ErbB2 inhibitor
化学名： N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tucatinib

Tucatinib is a potent and selective ErbB-2 (also called HER2) kinase inhibitor (IC50 = 7 nM). It exhibits >50-fold selectivity for ErbB-2 over EGFR. In vitro, Tucatinib inhibits ErbB-2 signaling activity and cell proliferation in ErbB-2-amplified breast cancer cell lines (BT-474). In vivo, Tucatinib (25-100 mg/kg) reduces tumor volume in breast and gastric xenograft mouse models.This compound is orally bioavailable.

化合物库 for Tucatinib

Tucatinib is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Tucatinib

分子量 480.52
公式 C26H24N8O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 937263-43-9
PubChem ID 51039094
InChI Key SDEAXTCZPQIFQM-UHFFFAOYSA-N
Smiles N=1C=NC(NC2=CC=C(OC=3C=CN4N=CN=C4C3)C(=C2)C)=C5C=C(C=CC15)NC6=NC(C)(C)CO6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tucatinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.05 100

制备储备液 for Tucatinib

以下数据基于产品分子量 480.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Tucatinib

参考文献是支持产品生物活性的出版物。

Kulukian et al (2020) Preclinical activity of HER2-selective Tyrosine Kinase inhibitor Tucatinib as a single agent or in combination with Trastuzumab or Docetaxel in solid tumor models. Mol.Cancer.Ther. 19 976 PMID: 32241871

If you know of a relevant reference for Tucatinib, please let us know.

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关键词: Tucatinib, Tucatinib supplier, Potent, selective, ErbB2, HER2, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, Kinases, orally, bioavailable, 7640, Tocris Bioscience

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该领域的文献

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