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TUG 891

Cat. No. 4601 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective FFA4 (GPR120) agonist
化学名： 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TUG 891

TUG 891 is a potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

许可信息

Sold under license from the University of Southern Denmark.

化合物库 for TUG 891

TUG 891 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TUG 891

分子量 364.41
公式 C23H21FO3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1374516-07-0
PubChem ID 57522038
InChI Key LPGBXHWIQNZEJB-UHFFFAOYSA-N
Smiles FC1=CC(COC2=CC=C(CCC(O)=O)C=C2)=C(C3=CC=C(C)C=C3)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TUG 891

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.44 100

制备储备液 for TUG 891

以下数据基于产品分子量 364.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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产品说明书 for TUG 891

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TUG 891

参考文献是支持产品生物活性的出版物。

Shimpukade et al (2012) Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 55 4511 PMID: 22519963

If you know of a relevant reference for TUG 891, please let us know.

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关键词: TUG 891, TUG 891 supplier, TUG891, GPR120, agonists, potent, selective, FFA1, FFA2, FFA3, cell, permeable, FFA4, free, fatty, acid, receptors, Free, Fatty, Acid, Receptors, 4601, Tocris Bioscience

3 篇 TUG 891 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TUG 891 的部分引用包括：

Maillard et al (2018) Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells. Reprod Biol Endocrinol 16 40 PMID: 29699561

Jeremy F et al (2019) Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell 179 1289-1305.e21 PMID: 31761534

J Silvio et al (2019) Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell 177 1933-1947.e25 PMID: 31160049

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