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说明： Potent and selective MMP-3 inhibitor
化学名： N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
纯度： ≥95% (HPLC)
生物活性 for UK 356618
UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for UK 356618
| 分子量 | 557.72 |
| 公式 | C34H43N3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 230961-08-7 |
| PubChem ID | 10370504 |
| InChI Key | JJHRUUKMPWUYIB-HVOSOHGQSA-N |
| Smiles | CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(NO)=O)C(N[C@H]([C@@](N[C@H](C)C3=CC=CC=C3)=O)C(C)(C)C)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UK 356618
参考文献 for UK 356618
参考文献是支持产品生物活性的出版物。
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774
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关键词: UK 356618, UK 356618 supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, metalloproteinase, Matrix, Metalloprotease, 4187, Tocris Bioscience
1 篇 UK 356618 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UK 356618 的部分引用包括：
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.