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说明： MCT inhibitor; also inhibits mitochondrial pyruvate carrier
化学名： 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
纯度： ≥98% (HPLC)
生物活性 for UK 5099
UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for UK 5099
UK 5099 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for UK 5099
| 分子量 | 288.3 |
| 公式 | C18H12N2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 56396-35-1 |
| PubChem ID | 6438504 |
| InChI Key | BIZNHCWFGNKBBZ-JLHYYAGUSA-N |
| Smiles | O=C(/C(C#N)=C/C2=CN(C3=CC=CC=C3)C1=CC=CC=C12)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UK 5099
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.83 | 100 |
制备储备液 for UK 5099
以下数据基于产品分子量 288.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.34 mL | 34.69 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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产品说明书 for UK 5099
参考文献 for UK 5099
参考文献是支持产品生物活性的出版物。
Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479 PMID: 8526859
Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607 PMID: 12887330
Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925 PMID: 16766717
If you know of a relevant reference for UK 5099, please let us know.
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关键词: UK 5099, UK 5099 supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, carriers, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Monocarboxylate, Transporters, 4186, Tocris Bioscience
7 篇 UK 5099 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UK 5099 的部分引用包括：
Keit Men et al (2020) A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci 23 1215-1228 PMID: 32807950
Rauckhorst et al (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab 6 1468 PMID: 29107293
Kaji et al (2015) SCFA transport in rat duodenum. Nat Chem Biol 308 G188 PMID: 25394661
Santosh et al (2021) The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep 34 108869 PMID: 33730581
Tompkins et al (2019) Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Rep 28 2608 PMID: 31484072
Lei et al (2019) Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell 179 1483-1498.e22 PMID: 31813625
Oliver J et al (2022) A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature 603 477-481 PMID: 35264789
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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