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UNC 2881

Cat. No. 6537 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Mer kinase inhibitor
化学名： 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UNC 2881

UNC 2881 is a potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC50 values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.

化合物库 for UNC 2881

UNC 2881 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for UNC 2881

分子量 463.58
公式 C25H33N7O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1493764-08-1
PubChem ID 71721525
InChI Key NPVXOWLPOFYACO-UHFFFAOYSA-N
Smiles CCCCNC1=NC=C(C(N[C@H]2CC[C@@H](CC2)O)=N1)C(NCC3=CC=C(N4C=CN=C4)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UNC 2881

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.18 50

制备储备液 for UNC 2881

以下数据基于产品分子量 463.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.31 mL 21.57 mL 43.14 mL
2.5 mM 0.86 mL 4.31 mL 8.63 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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参考文献 for UNC 2881

参考文献是支持产品生物活性的出版物。

Zhang et al (2013) Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 56 9693 PMID: 24219778

If you know of a relevant reference for UNC 2881, please let us know.

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关键词: UNC 2881, UNC 2881 supplier, UNC2881, Mer, kinase, inhibitors, inhibts, TAM, receptor, tyrosine, kinases, platelet, aggregation, Other, RTKs, 6537, Tocris Bioscience

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