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Submit ReviewValdecoxib
说明： Selective and potent COX-2 inhibitor
化学名： 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
纯度： ≥99% (HPLC)
生物活性 for Valdecoxib
Valdecoxib is a selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for Valdecoxib
Valdecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Valdecoxib
| 分子量 | 314.36 |
| 公式 | C16H14N2O3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 181695-72-7 |
| PubChem ID | 119607 |
| InChI Key | LNPDTQAFDNKSHK-UHFFFAOYSA-N |
| Smiles | CC1=C(C3=CC=C(S(=O)(N)=O)C=C3)C(C2=CC=CC=C2)=NO1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Valdecoxib
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.44 | 100 |
制备储备液 for Valdecoxib
以下数据基于产品分子量 314.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.81 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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产品说明书 for Valdecoxib
参考文献 for Valdecoxib
参考文献是支持产品生物活性的出版物。
Talley et al (2000) 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 43 775 PMID: 10715145
Walker et al (2001) A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 357 709 PMID: 11463341
Gierse et al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 312 1206 PMID: 15494548
If you know of a relevant reference for Valdecoxib, please let us know.
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关键词: Valdecoxib, Valdecoxib supplier, cyclooxygenase-2, COX-2, inhibitors, inhibits, selective, potent, NSAIDs, pfizer, non-steroidal, anti-inflammatory, Cyclooxygenase, 4206, Tocris Bioscience
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