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Submit ReviewVAS 2870
说明： NADPH oxidase (Nox) inhibitor
化学名： 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
纯度： ≥98% (HPLC)
生物活性 for VAS 2870
VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.
化合物库 for VAS 2870
VAS 2870 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for VAS 2870
| 分子量 | 360.39 |
| 公式 | C18H12N6OS |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 722456-31-7 |
| PubChem ID | 4058452 |
| InChI Key | HZSOKHVVANONPV-UHFFFAOYSA-N |
| Smiles | N1(N=NC2=C(N=CN=C12)SC3=NC4=CC=CC=C4O3)CC5=CC=CC=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for VAS 2870
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 36.04 | 100 |
制备储备液 for VAS 2870
以下数据基于产品分子量 360.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.75 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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产品说明书 for VAS 2870
参考文献 for VAS 2870
参考文献是支持产品生物活性的出版物。
Stielow et al (2006) Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun. 344 200 PMID: 16603125
Sancho and Fabregat et al (2011) The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol. 81 917 PMID: 21276422
ten Freyhaus et al (2006) Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res. 71 331 PMID: 16545786
Lu et al (2019) VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC Sci.Rep. 9 18852 PMID: 31827142
If you know of a relevant reference for VAS 2870, please let us know.
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关键词: VAS 2870, VAS 2870 supplier, VAS2870, NADPH, oxidase, inhibitors, inhibits, nicotinamide, adenine, dinucleotide, phosphate, NOX, reactive, oxygen, species, ROS, Oxidase, 6654, Tocris Bioscience
1 篇 VAS 2870 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VAS 2870 的部分引用包括：
Qiang et al (2021) Placenta-derived IL-32β activates neutrophils to promote preeclampsia development. Cell Mol Immunol 18 979-991 PMID: 33707686
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