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Vialinin A

Cat. No. 4988 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4988 has been discontinued.

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说明： Inhibitor of USP4 and USP5/IsoT
化学名： 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Vialinin A

Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anticancer activity decreasing viability in human colonic carcinoma cells. Inhibits VEGF-induced growth and proliferation of HUVECs and production of ROS, cytokines and chemokines in vitro. Also inhibits neovasularization in a mouse model.

技术数据 for Vialinin A

分子量 562.57
公式 C34H26O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 858134-23-3
PubChem ID 11563133
InChI Key NOJUKCRPSUMHQQ-UHFFFAOYSA-N
Smiles OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Vialinin A

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Vialinin A

参考文献是支持产品生物活性的出版物。

Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659

Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076

Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504

Sonowal et al (2018) Vialinin A, an edible mushroom-derived p-terphenyl antioxidant, prevents VEGF-induced neovascularization in vitro and in vivo. Oxid Med Cell Longev 1052102 PMID: 29541344

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关键词: Vialinin A, Vialinin A supplier, inhibitors, inhibits, ubquitin, ubquitination, ubiquitin-specific, peptidase, 4, USP4, USP5, isopeptidase, T, IsoT, UCH-L1, deubiquitinating, enzymes, DUB, TNF-a, TNF-alpha, TNF, anticancer, angiogenesis, antioxidant, nevasularization, Deubiquitinating, Enzymes, Antiangiogenics, 4988, Tocris Bioscience

1 篇 Vialinin A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Vialinin A 的部分引用包括：

Lin et al (2017) USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett 591 1677 PMID: 28477415

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