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Vinblastine sulfate

Cat. No. 1256 6 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Disrupts microtubules
化学名： Vincaleukoblastine
纯度： ≥95% (HPLC)
说明书
引用文献 (6)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Vinblastine sulfate

Vinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

技术数据 for Vinblastine sulfate

分子量 909.06
公式 C46H58N4O9.H2SO4
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 143-67-9
PubChem ID 241902
InChI Key KDQAABAKXDWYSZ-JKDPCDLQSA-N
Smiles OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Vinblastine sulfate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 90.91 100
DMSO 90.91 100

制备储备液 for Vinblastine sulfate

以下数据基于产品分子量 909.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.1 mL 5.5 mL 11 mL
5 mM 0.22 mL 1.1 mL 2.2 mL
10 mM 0.11 mL 0.55 mL 1.1 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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产品说明书 for Vinblastine sulfate

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Vinblastine sulfate

参考文献是支持产品生物活性的出版物。

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131 PMID: 9813016

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918 PMID: 8362985

Veldhoen et al (2012) The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736 PMID: 22430212

If you know of a relevant reference for Vinblastine sulfate, please let us know.

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关键词: Vinblastine sulfate, Vinblastine sulfate supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Microtubules, Autophagy, 1256, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Vinblastine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

6 篇 Vinblastine sulfate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Vinblastine sulfate 的部分引用包括：

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007

Bernier et al (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep 27 2895 PMID: 31167136

Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202

Ahmad et al (2010) Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Trop Life Sci Res 21 101 PMID: 24575203

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By Anonymous on 11/17/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007
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