Vinorelbine ditartrate

Name: Vinorelbine ditartrate
Brand: Tocris Bioscience
SKU: 3401

Cat. No. 3401 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3401 has been discontinued.

View all Microtubules products.

说明： Selective mitotic microtubule antagonist

别名： Navelbine

化学名： (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

纯度： ≥97% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Vinorelbine ditartrate

Vinorelbine ditartrate is a selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC₅₀ = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC₅₀ = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

技术数据 for Vinorelbine ditartrate

分子量	1079.1
公式	C₄₅H₅₄N₄O₈.2C₄H₆O₆
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	125317-39-7
PubChem ID	5311497
InChI Key	GBABOYUKABKIAF-IELIFDKJSA-N
Smiles	[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Vinorelbine ditartrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Vinorelbine ditartrate

参考文献是支持产品生物活性的出版物。

Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475 PMID: 9316630

Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinore. and its newer derivative vinflunine. Mol.Pharmacol. 60 225 PMID: 11408618

Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinbla. on centromere dynamics. Mol.Cancer Ther. 2 427 PMID: 12748304

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关键词: Vinorelbine ditartrate, Vinorelbine ditartrate supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin, chemotherapeutics, Navelbine, Microtubules, Mitosis, 3401, Tocris Bioscience

1 篇 Vinorelbine ditartrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Vinorelbine ditartrate 的部分引用包括：

Mavroeidis et al (2015) Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Front Cell Neurosci 47 455 PMID: 26095084