VPC 23019

Cat. No. 4195 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： S1P₁ and S1P₃ antagonist

化学名： 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide

纯度： ≥95% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for VPC 23019

VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P₁ and S1P₃ receptors (pK_i values are 7.86 and 5.93 respectively).

技术数据 for VPC 23019

分子量	372.4
公式	C₁₇H₂₉N₂O₅P
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	449173-19-7
PubChem ID	11588811
InChI Key	MRUSUGVVWGNKFE-MRXNPFEDSA-N
Smiles	O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VPC 23019

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	Acidified DMSO (5% 1N HCl in DMSO)	3.72	10 温和加热
	2eq. NaOH	18.62	50

制备储备液 for VPC 23019

以下数据基于产品分子量 372.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.37 mL	26.85 mL	53.71 mL
2.5 mM	1.07 mL	5.37 mL	10.74 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
25 mM	0.11 mL	0.54 mL	1.07 mL

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产品说明书 for VPC 23019

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VPC 23019

参考文献是支持产品生物活性的出版物。

Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833 PMID: 15590668

Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α₅β₁ and α_Vβ₃. J.Thromb.Haemost. 5 1292 PMID: 17403093

Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806 PMID: 17264352

If you know of a relevant reference for VPC 23019, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: VPC 23019, VPC 23019 supplier, VPC23019, sphingosine-1-phosphate, s1p1, s1p3, antagonists, s1p, sphingolipids, Sphingosine-1-phosphate, Receptors, 4195, Tocris Bioscience