主页 / 药理学 / Ion Channels / Potassium Channels / Inward Rectifier Potassium (Kir) Channels / Inward Rectifier Potassium (Kir) Channel Activators / VU 0071063

VU 0071063

Cat. No. 7057 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective activator of SUR1 Kir6.2 channels
化学名： 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 0071063

VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.

技术数据 for VU 0071063

分子量 326.4
公式 C18H22N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 333415-38-6
PubChem ID 590142
InChI Key ZFZAIHKQJBMYLO-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(CN2C=NC3=C2C(N(C)C(N3C)=O)=O)C=C1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0071063

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.63 5

制备储备液 for VU 0071063

以下数据基于产品分子量 326.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 61.27 mL 306.37 mL 612.75 mL
0.25 mM 12.25 mL 61.27 mL 122.55 mL
0.5 mM 6.13 mL 30.64 mL 61.27 mL
2.5 mM 1.23 mL 6.13 mL 12.25 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for VU 0071063

参考文献是支持产品生物活性的出版物。

Raphemot et al (2014) Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 85 858 PMID: 24646456

Kharade et al (2019) Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 370 350 PMID: 31201216

If you know of a relevant reference for VU 0071063, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Inward Rectifier Potassium (Kir) Channel Activators

关键词: VU 0071063, VU 0071063 supplier, VU0071063, selective, activators, potassium, channels, SUR1, Kir6.2, pancreatic, beta, cell, b-cells, Inward, rectifier, Potassium, Channels, 7057, Tocris Bioscience

篇 VU 0071063 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 VU 0071063 的引用文献。 您是否知道使用了 Tocris VU 0071063 的优秀论文？ 请告知我们.

VU 0071063 的评论

目前没有该产品的评论。 Be the first to review VU 0071063 and earn rewards!

Have you used VU 0071063?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review