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VU 0542270

Cat. No. 8151 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of Kir6.1 KATP channels
化学名： 1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 0542270

VU 0542270 is a selective inhibitor of Kir6.1/SUR2B KATP channels (IC50 = 104 nM). Shows no activity at other Kir channel types at up to 30 μM. Dose-dependently induces constriction of ductus arteriosus vessels.

技术数据 for VU 0542270

分子量 335.46
公式 C14H13N3OS3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1396814-79-1
PubChem ID 71795439
InChI Key HMFDAWDOVRPGGW-UHFFFAOYSA-N
Smiles O=C(NCC1=C(C)N=C(C2=CC=CS2)S1)NC3=CC=CS3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0542270

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.55 100

制备储备液 for VU 0542270

以下数据基于产品分子量 335.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.9 mL 29.81 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for VU 0542270

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for VU 0542270

参考文献是支持产品生物活性的出版物。

Li et al (2024) Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B KATP channels. Mol.Pharmacol. 105 202 PMID: 38302135

If you know of a relevant reference for VU 0542270, please let us know.

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关键词: VU 0542270, VU 0542270 supplier, VU0542270, Kir6.1, Kir, SUR2B, KATP, channel, selective, inhibitor, inhibitors, inhibits, blood, vessel, constrictor, Inward, rectifier, Potassium, Channels, 8151, Tocris Bioscience

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