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Submit ReviewVU 590 dihydrochloride
Discontinued Product
3891 has been discontinued.
View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Inhibitor of Kir1.1 (ROMK) and Kir7.1
化学名： 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
纯度： ≥97% (HPLC)
生物活性 for VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
技术数据 for VU 590 dihydrochloride
| 分子量 | 561.46 |
| 公式 | C24H32N4O7.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1783987-83-6 |
| PubChem ID | 71433535 |
| InChI Key | FRYYSUBAHIUBNJ-UHFFFAOYSA-N |
| Smiles | O=[N+](C(C=C2)=CC=C2CN1CCOCCOCCN(CC3=CC=C([N+]([O-])=O)C=C3)CCOCC1)[O-].Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 590 dihydrochloride
参考文献 for VU 590 dihydrochloride
参考文献是支持产品生物活性的出版物。
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094 PMID: 19706730
关键词: VU 590 dihydrochloride, VU 590 dihydrochloride supplier, Inhibitor, inhibitors, inhibits, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1, Inward, rectifier, Potassium, Channels, 3891, Tocris Bioscience
2 篇 VU 590 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VU 590 dihydrochloride 的部分引用包括：
Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42 PMID: 20926757
VU 590 dihydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies.
By
Anonymous on 10/31/2018
分析类型： In Vitro
种属： Human
Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.
