主页 / 药理学 / Ion Channels / Potassium Channels / Inward Rectifier Potassium (Kir) Channels / Inward Rectifier Potassium (Kir) Channel Blockers / VU 591 hydrochloride

VU 591 hydrochloride

Cat. No. 4197 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4197 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Selective Kir1.1 (ROMK) inhibitor
化学名： 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for VU 591 hydrochloride

VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

技术数据 for VU 591 hydrochloride

分子量 404.76
公式 C16H12N6O5.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1315380-70-1
PubChem ID 90488918
InChI Key PXLOUHLPDHEXCC-UHFFFAOYSA-N
Smiles O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VU 591 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for VU 591 hydrochloride

参考文献是支持产品生物活性的出版物。

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42 PMID: 20926757

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Inward Rectifier Potassium (Kir) Channel Blockers

关键词: VU 591 hydrochloride, VU 591 hydrochloride supplier, VU591, hydrochloride, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Inward, rectifier, Potassium, Channels, 4197, Tocris Bioscience

篇 VU 591 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 VU 591 hydrochloride 的引用文献。

VU 591 hydrochloride 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used VU 591 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.
By Anonymous on 01/16/2019
分析类型： In Vivo
种属： Mouse

VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side.Overall acts as a great measure for comparing blocking action.

review image