W146

Cat. No. 3602 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective S1P₁ receptor antagonist

别名： ML 056

化学名： [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

纯度： ≥98% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for W146

W146 is a potent sphingosine-1-phosphate receptor S1P₁ selective antagonist (K_i = 18 nM); displays no effect at S1P₂, S1P₃ or S1P₅. Enhances capillary leakage and restores lymphocyte egress in vivo.

技术数据 for W146

分子量	342.37
公式	C₁₆H₂₇N₂O₄P
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	909725-61-7
PubChem ID	6857802
InChI Key	FWJRVGZWNDOOFH-OAHLLOKOSA-N
Smiles	CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for W146

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	3eq. NaOH	6.85	20

制备储备液 for W146

以下数据基于产品分子量 342.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	14.6 mL	73.02 mL	146.04 mL
1 mM	2.92 mL	14.6 mL	29.21 mL
2 mM	1.46 mL	7.3 mL	14.6 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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产品说明书 for W146

分析证书/产品说明书

化学品安全技术说明书

参考文献 for W146

参考文献是支持产品生物活性的出版物。

Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635

If you know of a relevant reference for W146, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: W146, W146 supplier, potent, selective, sphingosine-1-phosphate, s1p1, antagonists, sphingolipids, ML056, ML, 056, Sphingosine-1-phosphate, Receptors, 3602, Tocris Bioscience