主页 / 细胞生物学 / Signal Transduction / Wnt Signaling / β-catenin / WAY 316606 hydrochloride

WAY 316606 hydrochloride

Cat. No. 4767 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
化学名： 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WAY 316606 hydrochloride

WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.

We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.

化合物库 for WAY 316606 hydrochloride

WAY 316606 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 316606 hydrochloride

分子量 484.94
公式 C18H19F3N2O4S2.HCl
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1781835-02-6
PubChem ID 25186563
InChI Key YLOYHLUHXQJNGO-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C1)(C2=CC=CC=C2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 316606 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.7 20

制备储备液 for WAY 316606 hydrochloride

以下数据基于产品分子量 484.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.31 mL 51.55 mL 103.11 mL
1 mM 2.06 mL 10.31 mL 20.62 mL
2 mM 1.03 mL 5.16 mL 10.31 mL
10 mM 0.21 mL 1.03 mL 2.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for WAY 316606 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for WAY 316606 hydrochloride

参考文献是支持产品生物活性的出版物。

Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190 PMID: 19932972

Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105 PMID: 19072540

Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063 PMID: 19254787

If you know of a relevant reference for WAY 316606 hydrochloride, please let us know.

按标靶查看相关产品

关键词: WAY 316606 hydrochloride, WAY 316606 hydrochloride supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Beta-catenin, 4767, Tocris Bioscience

1 篇 WAY 316606 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WAY 316606 hydrochloride 的部分引用包括：

Ichijo et al (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun 8 508 PMID: 28894084

您是否知道使用了 Tocris WAY 316606 hydrochloride 的优秀论文？ 请告知我们.

WAY 316606 hydrochloride 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used WAY 316606 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Exactly what it is supposed to be..
By Anonymous on 06/28/2020
种属： Human

We are a reference lab and needed to compare a questioned product to authentic WAY-316606. We generated our own purity and identity information on this product and confirmed the COA. The attached PDF shows that the infrared spectrum was an exact match with the questioned material. That's exactly what we needed to confirm.

review image

Pathways for WAY 316606 hydrochloride

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.