WEB 2086

Cat. No. 2339 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent PAF receptor antagonist

别名： Apafant

化学名： 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for WEB 2086

WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (K_i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

技术数据 for WEB 2086

分子量	455.96
公式	C₂₂H₂₂N₅O₂SCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	105219-56-5
PubChem ID	65889
InChI Key	JGPJQFOROWSRRS-UHFFFAOYSA-N
Smiles	CC1=NN=C2CN=C(C3=C(SC(CCC(=O)N4CCOCC4)=C3)N12)C1=CC=CC=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WEB 2086

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	45.6	100
	ethanol	45.6	100 温和加热

制备储备液 for WEB 2086

以下数据基于产品分子量 455.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.97 mL	21.93 mL
5 mM	0.44 mL	2.19 mL	4.39 mL
10 mM	0.22 mL	1.1 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for WEB 2086

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WEB 2086

参考文献是支持产品生物活性的出版物。

Dent et al (1989) Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS Lett. 244 365 PMID: 2537761

Sariahmetoglu et al (1998) Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. Pharmacol.Res. 38 173 PMID: 9782066

Cellai et al (2006) Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. Br.J.Cancer 94 1637 PMID: 16721373

If you know of a relevant reference for WEB 2086, please let us know.

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Platelet-Activating Factor (PAF) Receptors

关键词: WEB 2086, WEB 2086 supplier, Potent, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, WEB2086, Apafant, (PAF), 2339, Tocris Bioscience