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WIC1

Cat. No. 7580 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of Wnt/β-catenin signaling
化学名： N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WIC1

WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-cateninY489 and Tp63 expression.

技术数据 for WIC1

分子量 377.44
公式 C22H23N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 943083-58-7
PubChem ID 24746859
InChI Key YQXKWSNLAVFZJL-UHFFFAOYSA-N
Smiles CCN1CCN(C2=CC=C(C=C2)NC(C3=CC4=CC=CC=C4OC3=O)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WIC1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 0.75 2 温和加热

制备储备液 for WIC1

以下数据基于产品分子量 377.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.02 mM 132.47 mL 662.36 mL 1324.71 mL
0.1 mM 26.49 mL 132.47 mL 264.94 mL
0.2 mM 13.25 mL 66.24 mL 132.47 mL
1 mM 2.65 mL 13.25 mL 26.49 mL

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参考文献 for WIC1

参考文献是支持产品生物活性的出版物。

Aros et al (2020) High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 30 2055 PMID: 32075752

If you know of a relevant reference for WIC1, please let us know.

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关键词: WIC1, WIC1 supplier, canonical, Wnt, pathway, signaling, signalling, inhibitors, inhibits, catenin, Airway, Basal, Stem, Cell, ABSC, proliferation, β-cateninY489, Beta-catenin, 7580, Tocris Bioscience

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Pathways for WIC1

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.