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WIKI4

Cat. No. 4855 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent tankyrase inhibitor
化学名： 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WIKI4

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

技术数据 for WIKI4

分子量 521.59
公式 C29H23N5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 838818-26-1
PubChem ID 2984337
InChI Key RNUXIZKXJOGYQP-UHFFFAOYSA-N
Smiles O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WIKI4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.22 10

制备储备液 for WIKI4

以下数据基于产品分子量 521.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.86 mL 191.72 mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.59 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

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产品说明书 for WIKI4

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WIKI4

参考文献是支持产品生物活性的出版物。

James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457 PMID: 23227175

If you know of a relevant reference for WIKI4, please let us know.

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关键词: WIKI4, WIKI4 supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, Organoids, 4855, Tocris Bioscience

1 篇 WIKI4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WIKI4 的部分引用包括：

Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927

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Stem Cell Research Product Guide

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