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Submit ReviewWiskostatin
说明： N-WASP inhibitor; inhibits Arp2/3 activation
化学名： 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
纯度： ≥99% (HPLC)
生物活性 for Wiskostatin
Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
化合物库 for Wiskostatin
Wiskostatin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Wiskostatin
| 分子量 | 426.15 |
| 公式 | C17H18Br2N2O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 253449-04-6 |
| PubChem ID | 2775510 |
| InChI Key | XUBJEDZHBUPBKL-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Wiskostatin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 42.62 | 100 |
制备储备液 for Wiskostatin
以下数据基于产品分子量 426.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.73 mL | 23.47 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.69 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for Wiskostatin
参考文献 for Wiskostatin
参考文献是支持产品生物活性的出版物。
Wegner et al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912 PMID: 18430734
Peterson et al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747 PMID: 15235593
Guerriero and Weisz et al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562 PMID: 17092993
If you know of a relevant reference for Wiskostatin, please let us know.
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关键词: Wiskostatin, Wiskostatin supplier, Arp2/3, complex, n-wasp, wiskott-aldrich, syndrome, inhibitors, inhibits, actin, polymerization, 3,6-Dibromo-a-[(dimethylamino)methyl]-9H-cabazole-9-ethanol, Actin, 4434, Tocris Bioscience
3 篇 Wiskostatin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Wiskostatin 的部分引用包括：
Rassokhin and Pakhomov (2014) Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys 69 555 PMID: 24488232
Yogaditya et al (2021) A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane. Sci Adv 7 PMID: 33771860
Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715
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