Withaferin A

Name: Withaferin A
Brand: Tocris Bioscience
SKU: 2816
Rating: 4.5 (2 reviews)

Cat. No. 2816 7 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibits NF-κB activation

化学名： (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

纯度： ≥98% (HPLC)

说明书

引用文献 (7)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Withaferin A

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC₅₀ = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

技术数据 for Withaferin A

分子量	470.6
公式	C₂₈H₃₈O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	5119-48-2
PubChem ID	45489105
InChI Key	DBRXOUCRJQVYJQ-WDBPBROTSA-N
Smiles	O=C1[C@@]2(C)[C@@]([C@H]5C[C@]3([H])C2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@H]([C@]6([H])OC(C(CO)=C(C)C6)=O)C)(O5)[C@@H](O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Withaferin A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	4.71	10

制备储备液 for Withaferin A

以下数据基于产品分子量 470.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	21.25 mL	106.25 mL	212.49 mL
0.5 mM	4.25 mL	21.25 mL	42.5 mL
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL

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产品说明书 for Withaferin A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Withaferin A

参考文献是支持产品生物活性的出版物。

Mohan et al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7 115 PMID: 15516832

Yang et al (2007) The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol. 71 426 PMID: 17093135

Kaileh et al (2007) Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem. 282 4253 PMID: 17150968

Joshi et al (2021) Withaferin A induces heat shock response and ameliorates disease progression in a mouse model of Huntington's disease. Mol.Neurobiol. 58 3992 PMID: 33904021

If you know of a relevant reference for Withaferin A, please let us know.

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关键词: Withaferin A, Withaferin A supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, WithaferinA, NF-kB/IkB, 2816, Tocris Bioscience

7 篇 Withaferin A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Withaferin A 的部分引用包括：

Andersson et al (2018) Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight 3 PMID: 30333314

Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693

Hatzold et al (2016) Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. Elife 5 PMID: 27240166

Trendelenburg et al (2012) TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of AVNA. Skelet Muscle 2 3 PMID: 22313861

Yadav et al (2010) Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) 88 1243 PMID: 20798912

Yang et al (2016) The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Neural Plast 7 11385 PMID: 27150562

Martorana et al (2015) Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes. EMBO J 2015 381964 PMID: 26266054

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Withaferin A 的评论

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42 perturbagens used the zebrafish DASPEI screen.

By Anonymous on 12/17/2019

分析类型： In Vivo

种属： Other

细胞系/组织： larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

Withaferin inhibits LPS-induced TNFalpha production in macrophages.

By Christopher Trummer on 10/22/2018

分析类型： In Vitro

种属： Mouse

细胞系/组织： Macrophages

RAW macrophages were stimulated with Withaferin (1 µM) alone or in the presence of LPS (200 ng/ml) for 8 h to follow TNFalpha mRNA expression using qPCR. Withaferin significantly inhibited LPS-induced TNFalpha production.

Pathways for Withaferin A

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.