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WZB 117

Cat. No. 6143 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： GLUT inhibitor
化学名： 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WZB 117

WZB 117 is a GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-methylglucose (3MG) uptake in vitro (Ki = 6 μM). Suppresses tumor growth in a nude mouse model.

化合物库 for WZB 117

WZB 117 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WZB 117

分子量 368.31
公式 C20H13FO6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1223397-11-2
PubChem ID 46830365
InChI Key FRSWCCBXIHFKKY-UHFFFAOYSA-N
Smiles OC1=CC=CC(C(OC2=C(C(F)=CC=C2)OC(C3=CC(O)=CC=C3)=O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WZB 117

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.83 100
ethanol 36.83 100

制备储备液 for WZB 117

以下数据基于产品分子量 368.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.15 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for WZB 117

参考文献是支持产品生物活性的出版物。

Ojelabi et al (2016) WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site. J.Biol.Chem. 291 26762 PMID: 27836974

Liu et al (2012) A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol.Cancer Ther. 11 1672 PMID: 22689530

Koch et al (2015) Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 6 32748 PMID: 26293674

If you know of a relevant reference for WZB 117, please let us know.

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关键词: WZB 117, WZB 117 supplier, WZB117, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, GLUT3, Transporters, 6143, Tocris Bioscience

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