XL 184

Cat. No. 5422 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent VEGFR inhibitor; also inhibits other RTKs

别名： Cabozantinib,BMS 907351

化学名： N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for XL 184

XL 184 is a potent VEGFR inhibitor (IC₅₀ = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC₅₀ values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

化合物库 for XL 184

XL 184 is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for XL 184

分子量	501.51
公式	C₂₈H₂₄FN₃O₅
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	849217-68-1
PubChem ID	25102847
InChI Key	ONIQOQHATWINJY-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1OC)N=CC=C2OC3=CC=C(NC(C4(CC4)C(NC5=CC=C(F)C=C5)=O)=O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XL 184

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	50.15	100

制备储备液 for XL 184

以下数据基于产品分子量 501.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL
10 mM	0.2 mL	1 mL	1.99 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for XL 184

分析证书/产品说明书

化学品安全技术说明书

参考文献 for XL 184

参考文献是支持产品生物活性的出版物。

You et al (2012) VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 71 4758 PMID: 21613405

Yakes et al (2011) Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol.Cancer Ther. 10 2298 PMID: 21926191

If you know of a relevant reference for XL 184, please let us know.

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关键词: XL 184, XL 184 supplier, Potent, VEGFR, inhibitors, inhibits, HGFR, HGF, receptor, vascular, endothelial, growth, factors, receptor,, tyrosine, kinases, RTKs, c-Met, KIT, FLT4, AXL, FLT3, FLT1, Tie2, apoptosis, metastasis, antiangiogenics, angiogenesis, antitumor, antitumour, XL184, Cabozantinib, BMS, 907351, MET, Receptors, Other, 5422, Tocris Bioscience

1 篇 XL 184 的引用文献

引用文献是使用了 Tocris 产品的出版物。 XL 184 的部分引用包括：

Martín-Segura et al (2019) Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. Front Neurol 10 675 PMID: 31293510

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for XL 184

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.