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Y-26763

Cat. No. 2076 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Kir6 (KATP) channel opener
化学名： N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Y-26763

Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

技术数据 for Y-26763

分子量 276.29
公式 C14H16N2O4
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 127408-31-5
PubChem ID 121878
InChI Key IWTCFIIOUXJOOV-OLZOCXBDSA-N
Smiles CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Y-26763

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 27.63 100

制备储备液 for Y-26763

以下数据基于产品分子量 276.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.19 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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参考文献 for Y-26763

参考文献是支持产品生物活性的出版物。

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197 PMID: 9128839

Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of Ins release from human pancreatic β-cells Eur.J.Pharmacol. 486 133 PMID: 14975702

If you know of a relevant reference for Y-26763, please let us know.

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关键词: Y-26763, Y-26763 supplier, KATP, channel, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Channels, 2076, Tocris Bioscience

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Y-26763 的评论

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Y-26763 was used to Kir2 channels to understand channel opening..
By Anonymous on 11/29/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293

Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.

review image