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Y-26763

Cat. No. 2076 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2076 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Kir6 (KATP) channel opener
化学名： N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Y-26763

Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

技术数据 for Y-26763

分子量 276.29
公式 C14H16N2O4
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 127408-31-5
PubChem ID 121878
InChI Key IWTCFIIOUXJOOV-OLZOCXBDSA-N
Smiles CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Y-26763

参考文献是支持产品生物活性的出版物。

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197 PMID: 9128839

Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of Ins release from human pancreatic β-cells Eur.J.Pharmacol. 486 133 PMID: 14975702

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关键词: Y-26763, Y-26763 supplier, KATP, channel, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Channels, 2076, Tocris Bioscience

篇 Y-26763 的引用文献

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Y-26763 was used to Kir2 channels to understand channel opening..
By Anonymous on 11/29/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293

Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.

review image