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Y-27152

Cat. No. 2077 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2077 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
化学名： N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Y-27152

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

技术数据 for Y-27152

分子量 366.41
公式 C21H22N2O4
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 127408-30-4
PubChem ID 6918184
InChI Key RHFUXPCCELGMFC-UXHICEINSA-N
Smiles CC(=O)N(OCC1=CC=CC=C1)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Y-27152

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参考文献 for Y-27152

参考文献是支持产品生物活性的出版物。

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197 PMID: 9128839

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关键词: Y-27152, Y-27152 supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Potassium, Channels, 2077, Tocris Bioscience

篇 Y-27152 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Product was used on Kir2.2 channels to understand channel modulation.
By Anonymous on 11/29/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293

Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.

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