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YC 1

Cat. No. 4307 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
化学名： 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for YC 1

YC 1 is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

化合物库 for YC 1

YC 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for YC 1

分子量 304.34
公式 C19H16N2O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 170632-47-0
PubChem ID 5712
InChI Key OQQVFCKUDYMWGV-UHFFFAOYSA-N
Smiles OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for YC 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.43 100
ethanol 15.22 50

制备储备液 for YC 1

以下数据基于产品分子量 304.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.86 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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关键词: YC 1, YC 1 supplier, YC1, soluble, guanylyl, cyclase, sGC, activators, platelet, aggregation, cGMP, antiproliferatives, G1, cell, cycle, arrest, inducers, p21, CDK2, Guanylyl, Cyclase, Cell, Cycle, Inhibitors, Enzyme, Substrates, /, Activators, 4307, Tocris Bioscience

2 篇 YC 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 YC 1 的部分引用包括：

Shukla et al (2017) MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart dFdCyd Resistance to Pancreatic Cancer. Cancer Cell 32 71 PMID: 28697344

Bellamy and Garthwaite (2002) Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells. Br J Pharmacol 136 95 PMID: 11976273

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