YM 244769

Cat. No. 4544 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Na⁺/Ca²⁺ exchange inhibitor (reverse mode); neuroprotective

化学名： N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for YM 244769

YM 244769 is an inhibitor of the reverse mode of Na⁺/Ca²⁺ exchange (NCX). Potently inhibits Na⁺-dependent ⁴⁵Ca²⁺ uptake (IC₅₀ values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na⁺ and Ca²⁺ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

化合物库 for YM 244769

YM 244769 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for YM 244769

分子量	516.39
公式	C₂₆H₂₂FN₃O₃.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1780390-65-9
PubChem ID	90488952
InChI Key	OCKIUNLKEPKCRE-UHFFFAOYSA-N
Smiles	NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for YM 244769

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	51.64	100

制备储备液 for YM 244769

以下数据基于产品分子量 516.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.37 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for YM 244769

分析证书/产品说明书

化学品安全技术说明书

参考文献 for YM 244769

参考文献是支持产品生物活性的出版物。

Iwamoto et al (2007) Na⁺/Ca²⁺ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 7 188 PMID: 17896959

Iwamoto and Kita (2006) YM-244769, a novel Na⁺/Ca²⁺ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 70 2075 PMID: 16973719

If you know of a relevant reference for YM 244769, please let us know.

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关键词: YM 244769, YM 244769 supplier, YM244769, anti-ischemic, anti-ischaemic, hypoxia/reoxygenation, injury, neuroprotective, Na+, Ca2+, exchangers, NCX, NCX3, NCX2, NCX1, inhibitors, inhibits, reverse, mode, selective, Na+/Ca2+, Exchanger, 4544, Tocris Bioscience