YNT 185

Cat. No. 6739 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective OX₂ agonist

化学名： 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for YNT 185

YNT 185 is a potent and selective orexin OX₂ receptor agonist (EC₅₀ = 28 nM at human OX₂ expressed in CHO cells). Displays approximately 100-fold selectivity for OX₂ over OX₁ (EC₅₀ = 2.75 μM at human OX₁ expressed in CHO cells). Depolarizes OX₂-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

化合物库 for YNT 185

YNT 185 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for YNT 185

分子量	688.66
公式	C₃₃H₃₇N₅O₅S.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1804978-82-2
PubChem ID	140307520
InChI Key	AIORBDHFHVKRIY-UHFFFAOYSA-N
Smiles	COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for YNT 185

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	68.87	100
	DMSO	68.87	100

制备储备液 for YNT 185

以下数据基于产品分子量 688.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.45 mL	7.26 mL	14.52 mL
5 mM	0.29 mL	1.45 mL	2.9 mL
10 mM	0.15 mL	0.73 mL	1.45 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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产品说明书 for YNT 185

分析证书/产品说明书

化学品安全技术说明书

参考文献 for YNT 185

参考文献是支持产品生物活性的出版物。

Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID: 26267383

Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID: 28507129

If you know of a relevant reference for YNT 185, please let us know.

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关键词: YNT 185, YNT 185 supplier, YNT185, orexin, receptor, 2, agonists, agonism, OX1, selective, potent, sleep, wake, cycle, nacolepsy, cataplexy, OX2, Receptor, 6739, Tocris Bioscience

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