主页 / 药理学 / Ion Channels / Calcium Channels / Voltage-gated Calcium Channels (CaV) / CaV3.x Channels (T-type) / CaV3.x Channel (T-type) Blockers / Z 944

Z 944

Cat. No. 6367 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： CaV3.x blocker
化学名： 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Z 944

Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

化合物库 for Z 944

Z 944 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Z 944

分子量 383.89
公式 C19H27ClFN3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1199236-64-0
PubChem ID 44540045
InChI Key JOCLITFYIMJMNK-UHFFFAOYSA-N
Smiles CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Z 944

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.39 100
ethanol 38.39 100

制备储备液 for Z 944

以下数据基于产品分子量 383.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.6 mL 13.02 mL 26.05 mL
5 mM 0.52 mL 2.6 mL 5.21 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for Z 944

参考文献是支持产品生物活性的出版物。

Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID: 22344687

Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID: 26274319

If you know of a relevant reference for Z 944, please let us know.

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关键词: Z 944, Z 944 supplier, Z944, T-type, calcium, channel, blockers, anti-epileptic, in, vivo, Cav3.1, Cav3.2, Cav3.3, Ca2+, blocks, Cav3.x, Channels, 6367, Tocris Bioscience

2 篇 Z 944 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Z 944 的部分引用包括：

Praveen et al (2020) A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Cell 183 522-536.e19 PMID: 32997977

Sean M et al (2021) Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon. Elife 10 PMID: 33399536

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