Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewZ-DEVD-FMK Caspase-3 Inhibitor
说明： Caspase-3 Inhibitor
纯度： ≥95% (HPLC)
生物活性 for Z-DEVD-FMK Caspase-3 Inhibitor
Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.
技术数据 for Z-DEVD-FMK Caspase-3 Inhibitor
| 分子量 | 668.67 |
| 公式 | C30H41FN4O12 |
| 序列 |
DEVD (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = DL-Asp(OMe)-fluoromethylketone) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 634911-78-7 |
| InChI Key | GBJVAVGBSGRRKN-OXMHKTTFSA-N |
| Smiles | [H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C(C)C)=O)CCC(OC)=O)=O)CC(OC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Z-DEVD-FMK Caspase-3 Inhibitor
| 溶解性 | Soluble to 1 mg/ml in DMSO |
产品说明书 for Z-DEVD-FMK Caspase-3 Inhibitor
参考文献 for Z-DEVD-FMK Caspase-3 Inhibitor
参考文献是支持产品生物活性的出版物。
Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057 PMID: 9774422
Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954
Kugawa et al (2000) Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930 PMID: 10963298
Yakovlev et al (1997) Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J.Neurosci. 17 7415 PMID: 9295387
If you know of a relevant reference for Z-DEVD-FMK Caspase-3 Inhibitor, please let us know.
按产品操作查看相关产品
关键词: Z-DEVD-FMK Caspase-3 Inhibitor, Z-DEVD-FMK Caspase-3 Inhibitor supplier, cell-permeable, irreversible, caspase-3, inhibitors, inhibits, caspases, proteinases, proteases, in, vivo, apoptosis, neuroprotective, brain, injury, Caspases, 8009, Tocris Bioscience
篇 Z-DEVD-FMK Caspase-3 Inhibitor 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Z-DEVD-FMK Caspase-3 Inhibitor 的引用文献。 您是否知道使用了 Tocris Z-DEVD-FMK Caspase-3 Inhibitor 的优秀论文？ 请告知我们.
Z-DEVD-FMK Caspase-3 Inhibitor 的评论
目前没有该产品的评论。 Be the first to review Z-DEVD-FMK Caspase-3 Inhibitor and earn rewards!
Have you used Z-DEVD-FMK Caspase-3 Inhibitor?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.