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说明： Caspase-3 inhibitor
化学名： Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
生物活性 for Z-DQMD-FMK
Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
技术数据 for Z-DQMD-FMK
| 分子量 | 685.72 |
| 公式 | C29H40FN5O11S |
| 序列 |
DQMD (Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone) |
| 储存 | Desiccate at -20°C |
| PubChem ID | 644197 |
| InChI Key | QFITYVNVMNJELE-TUFLPTIASA-N |
| Smiles | [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Z-DQMD-FMK
参考文献 for Z-DQMD-FMK
参考文献是支持产品生物活性的出版物。
Izban et al (2001) Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells. Mod.Pathol. 14 297 PMID: 11301346
Bang et al (2004) Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073
Chou et al (2004) Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death. Biochem.J. 383 63 PMID: 15198639
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关键词: Z-DQMD-FMK, Z-DQMD-FMK supplier, Caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2168, Tocris Bioscience
1 篇 Z-DQMD-FMK 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Z-DQMD-FMK 的部分引用包括：
Allam et al (2018) HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. PLoS One 13 e0194185 PMID: 29601578
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.