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(Z)-FeCP-oxindole

Cat. No. 3883 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3883 has been discontinued.

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说明： Selective VEGFR-2 inhibitor
化学名： (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (Z)-FeCP-oxindole

Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.

Geometric Isomer also available.

技术数据 for (Z)-FeCP-oxindole

分子量 329.17
公式 C19H15FeNO
储存 Store at +4°C
CAS Number 1137967-28-2
PubChem ID 90488891
InChI Key MTGBTDOTYGXLBK-UHFFFAOYSA-M
Smiles [Fe++].[CH-]1C=CC=C1.O=C1NC2=CC=CC=C2\C1=C\C1=CC=C[CH-]1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (Z)-FeCP-oxindole

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (Z)-FeCP-oxindole

参考文献是支持产品生物活性的出版物。

Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402

Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918

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关键词: (Z)-FeCP-oxindole, (Z)-FeCP-oxindole supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, 3883, Tocris Bioscience

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该领域的文献

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for (Z)-FeCP-oxindole

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.