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Z-VAD-FMK

Cat. No. 2163 32 篇引用文献 3 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cell-permeable, irreversible caspase inhibitor
化学名： Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
纯度： ≥95% (HPLC)
说明书
引用文献 (32)
评论 (3)
文献 (5)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

技术数据 for Z-VAD-FMK

分子量 467.49
公式 C22H30FN3O7
序列 VAD

(Modifications: Val-1 = Z-Val, Asp-3 = DL-Asp-(OMe)-fluoromethylketone)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 634911-81-9
PubChem ID 5497174
InChI Key MIFGOLAMNLSLGH-SXUUOERCSA-N
Smiles [H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C)=O)C(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Z-VAD-FMK

溶解性 Soluble to 9.35 mg/ml in DMSO

产品说明书 for Z-VAD-FMK

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Z-VAD-FMK

参考文献是支持产品生物活性的出版物。

Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21 PMID: 8670109

Kunstle et al (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 55 5 PMID: 9093874

Garcia-Calvo et al (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 273 32608 PMID: 9829999

King et al (1998) Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 12 1553 PMID: 9766499

If you know of a relevant reference for Z-VAD-FMK, please let us know.

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关键词: Z-VAD-FMK, Z-VAD-FMK supplier, Cell-permeable, irreversible, caspases, inhibitors, inhibits, Proteinases, Proteases, Caspases, Inflammasomes, 2163, Tocris Bioscience

32 篇 Z-VAD-FMK 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Z-VAD-FMK 的部分引用包括：

Bae et al (2019) Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes. Cells 8 PMID: 30965677

Vago et al (2012) Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. J Leukoc Biol 92 249 PMID: 22493082

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Woo et al (2012) Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem 287 3963 PMID: 22117079

Silva et al (2015) A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Apoptosis 14 1070 PMID: 25602147

Bonnefond et al (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Oncoscience 20 535 PMID: 25627260

Amantini et al (2015) Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. Cell Death Dis 2 395 PMID: 26097873

Baron et al (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Mol Cell Biol 6 e1629 PMID: 25654762

Hu et al (2015) NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Clin Cancer Res 35 379 PMID: 25368386

Galbiati et al (2014) Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes. J Invest Dermatol 134 2719 PMID: 24780928

Cook et al (2012) Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Oncotarget 72 3337 PMID: 22752300

Sullivan et al (2012) ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Cell Cycle 8 646 PMID: 22660439

Karabay et al (2016) Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells International Journal of Molecular Sciences 17 1123 PMID: 27428957

Nicolson (2014) Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol 88 4132 PMID: 24478436

Piao et al (2014) The ethyl acetate fraction of Sargassum muticum attenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes. Pharm Biol 52 1110 PMID: 24617288

Greer et al (2018) ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget 9 18454 PMID: 29719618

Shacham-Silverberg et al (2018) Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration. Cell Death Dis 9 1116 PMID: 30389906

Retamal-Díaz et al (2017) US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Front Immunol 8 1523 PMID: 29176979

Sagher et al (2014) The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int 14 75 PMID: 25324692

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449 PMID: 25158854

Kuang et al (2015) Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxalip. Mol Oncol 9 1799 PMID: 26160429

Sullivan et al (2015) Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle 14 1771 PMID: 25853217

Hight et al (2014) A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Evid Based Complement Alternat Med 20 2126 PMID: 24573549

Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Mar Drugs 2013 857929 PMID: 23762164

Kim et al (2013) Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells. Mol Cancer Res 11 418 PMID: 23389088

Lee et al (2011) GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition. Korean J Physiol Pharmacol 15 149 PMID: 21860593

García-Escudero et al (2008) Glioma regression in vitro and in vivo by a suicide combined treatment. Cancer Res 6 407 PMID: 18337448

Bagnjuk et al (2019) Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov 5 67 PMID: 30774995

Moon et al (2015) mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep 12 102 PMID: 26119735

Im-aram et al (2013) The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells. PLoS One 8 e75455 PMID: 24086535

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773

Kim et al (2013) A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis 4 e750 PMID: 23907464

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Used for FACS.
By Anonymous on 06/06/2020
分析类型： In Vivo
种属： Mouse
细胞系/组织： phagocyte

25 μM

review image
It blocks caspases activity in cultured microglia.
By Anonymous on 09/27/2019
分析类型： In Vitro
种属： Rat

We pretreated to cultured microglia to inhibit caspases activity at 20microM

Caspase inhibitor.
By Paramananda Saikia on 01/04/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： AML12

AML12 hepatocytes were cultured and were per-treated with Z-VAD-FMK.

12.5 micro molar concentration was used in the study.

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