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ZAP 180013

Cat. No. 6821 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Zap70 inhibitor; inhibits interaction with ITAMs
化学名： 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ZAP 180013

ZAP 180013 is a zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

化合物库 for ZAP 180013

ZAP 180013 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ZAP 180013

分子量 454.32
公式 C19H17Cl2N3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 873080-25-2
PubChem ID 2988718
InChI Key GTWKIPDKVRLUKN-UHFFFAOYSA-N
Smiles O=C(N(CC1=CC=C(Cl)C=C1)CC2=CC=CO2)C3=NC(S(=O)(CC)=O)=NC=C3Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZAP 180013

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.43 100

制备储备液 for ZAP 180013

以下数据基于产品分子量 454.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.01 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for ZAP 180013

参考文献是支持产品生物活性的出版物。

Visperas et al (2017) Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 22 324 PMID: 27932698

If you know of a relevant reference for ZAP 180013, please let us know.

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关键词: ZAP 180013, ZAP 180013 supplier, ZAP180013, zap70, zap-70, zeta, chain, associated, protein, kinase, 70, inhibitors, inhibits, immunoreceptor, tyrosine, activation, motif, t-cell, antigen, receptor, ITAMs, Other, RTKs, 6821, Tocris Bioscience

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