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Zebularine

Cat. No. 2293 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： DNA methyltransferase and cytidine deaminase inhibitor
别名： NSC 309132
化学名： 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Zebularine

Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

技术数据 for Zebularine

分子量 228.2
公式 C9H12N2O5
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 3690-10-6
PubChem ID 100016
InChI Key RPQZTTQVRYEKCR-WCTZXXKLSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CC=C2)=O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zebularine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 22.82 100
DMSO 22.82 100

制备储备液 for Zebularine

以下数据基于产品分子量 228.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.91 mL 43.82 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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产品说明书 for Zebularine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Zebularine

参考文献是支持产品生物活性的出版物。

Laliberte et al (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 30 7 PMID: 1375134

Ben-Kasus et al (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 70 121 PMID: 15885659

Naeem et al (2012) DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print]

If you know of a relevant reference for Zebularine, please let us know.

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关键词: Zebularine, Zebularine supplier, DNA, methyltransferase, inhibitors, inhibits, Transferases, cytidine, deaminases, NSC309132, dnmt, cardiomyocyte, differentiation, mesenchymal, stem, cells, epigenetics, NSC, 309132, Methyltransferases, Deaminases, Cardiomyocyte, Stem, Cells, Mesenchymal, 2293, Tocris Bioscience

4 篇 Zebularine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zebularine 的部分引用包括：

Trowbridge et al (2012) Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Gastroenterology 26 344 PMID: 22345515

Soltoff and Lannon (2013) Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One 8 e72881 PMID: 24009711

Zou et al (2019) The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation. Front Immunol 10 1950 PMID: 31475011

Biergans et al (2012) DNA methylation mediates the discriminatory power of associative long-term memory in honeybees. PLoS One 7 e39349 PMID: 22724000

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.