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ZJ 43

Cat. No. 2675 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
化学名： N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ZJ 43

ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

许可信息

Sold with the permission of Acenta Discovery, Inc.

技术数据 for ZJ 43

分子量 304.3
公式 C12H20N2O7
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 723331-20-2
PubChem ID 11722553
InChI Key BSGWCSGMXAVYRT-YUMQZZPRSA-N
Smiles CC(C[C@@]([H])(C(O)=O)NC(N[C@@]([H])(CCC(O)=O)C(O)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZJ 43

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 30.43 100
DMSO 30.43 100

制备储备液 for ZJ 43

以下数据基于产品分子量 304.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.86 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for ZJ 43

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for ZJ 43

参考文献是支持产品生物活性的出版物。

Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876 PMID: 15140187

Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015 PMID: 16341066

Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147 PMID: 17241276

If you know of a relevant reference for ZJ 43, please let us know.

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关键词: ZJ 43, ZJ 43 supplier, Glutamate, carboxypeptidase, II, III, NAALADase, NAAG, peptidase, inhibitors, inhibits, Carboxypeptidase, GCP, Peptidase, Proteinases, Proteases, ZJ43, Miscellaneous, 2675, Tocris Bioscience

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