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ZNL 02-096

Cat. No. 7240 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective Wee1 Degrader (PROTAC®)
化学名： 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ZNL 02-096

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

Wee1 antibody validated for Western Blot also available: Catalog # NBP1-33506.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from Dana-Farber Cancer Institute.

技术数据 for ZNL 02-096

分子量 799.89
公式 C42H45N11O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2414418-49-6
PubChem ID 153555373
InChI Key LZUDSNUROXNVPH-UHFFFAOYSA-N
Smiles CC(O)(C1=NC(N2N(C(C3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)C=C4)=O)CC=C)=CC=C1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZNL 02-096

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.99 50

制备储备液 for ZNL 02-096

以下数据基于产品分子量 799.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.5 mL 12.5 mL 25 mL
2.5 mM 0.5 mL 2.5 mL 5 mL
5 mM 0.25 mL 1.25 mL 2.5 mL
25 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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参考文献 for ZNL 02-096

参考文献是支持产品生物活性的出版物。

Li et al (2020) Development and characterization of a Wee1 kinase degrader. Cell Chem.Biol. 27 57 PMID: 31735695

If you know of a relevant reference for ZNL 02-096, please let us know.

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关键词: ZNL 02-096, ZNL 02-096 supplier, ZNL02-096, Wee1, Degrader, PROTAC, PROTACs, AZD, 1775, selective, TPD, targeted, protein, degradation, Checkpoint, Kinases, Control, Kinase, Degraders, 7240, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia