主页 / 药理学 / Transporters / Ion Pumps/Transporters / Na+/H+ Exchanger / Na+/H+ Exchanger Inhibitors / Zoniporide dihydrochloride

Zoniporide dihydrochloride

Cat. No. 2727 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective NHE1 inhibitor
别名： CP 597396
化学名： [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Zoniporide dihydrochloride

Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

许可信息

Sold for research purposes under agreement from Pfizer Inc

化合物库 for Zoniporide dihydrochloride

Zoniporide dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Zoniporide dihydrochloride

分子量 393.27
公式 C17H16N6O.2HCl
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 241799-10-0
PubChem ID 22267855
InChI Key ARZNPJAGKWHEHT-UHFFFAOYSA-N
Smiles O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zoniporide dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 3.93 10
DMSO 39.33 100

制备储备液 for Zoniporide dihydrochloride

以下数据基于产品分子量 393.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.43 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for Zoniporide dihydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Zoniporide dihydrochloride

参考文献是支持产品生物活性的出版物。

Knight et al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254 PMID: 11259552

Marala et al (2002) Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 451 37 PMID: 12223226

Clements-Jewery et al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57 PMID: 15037516

If you know of a relevant reference for Zoniporide dihydrochloride, please let us know.

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关键词: Zoniporide dihydrochloride, Zoniporide dihydrochloride supplier, Selective, NHE-1, inhibitors, inhibits, Ion, Pumps, Transporters, Sodium-hydrogen, exchanger, isoform-1, CP597396, CP, 597396, Na+/H+, Exchanger, 2727, Tocris Bioscience

2 篇 Zoniporide dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zoniporide dihydrochloride 的部分引用包括：

Féraille et al (2014) NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity. PLoS One 9 e87239 PMID: 24466344

Goldman et al (2011) The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. PLoS One 6 e23835 PMID: 21887327

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