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Description: Activator of procaspase-3; pro-apoptotic
Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Purity: ≥98% (HPLC)
Biological Activity for PAC 1
PAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).
Technical Data for PAC 1
| M. Wt | 392.5 |
| Formula | C23H28N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315183-21-2 |
| PubChem ID | 9675990 |
| InChI Key | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| Smiles | O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PAC 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 29.44 | 75 | |
| DMSO | 39.25 | 100 |
Preparing Stock Solutions for PAC 1
The following data is based on the product molecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for PAC 1
References for PAC 1
References are publications that support the biological activity of the product.
Putt et al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol. 2 543 PMID: 16936720
Peterson et al (2009) Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J.Med.Chem. 52 5721 PMID: 19708658
If you know of a relevant reference for PAC 1, please let us know.
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Keywords: PAC 1, PAC 1 supplier, activators, procaspase-3, proapoptotic, Caspases, Proteinases, Proteases, PAC1, Enzyme, Substrates, /, Activators, 2581, Tocris Bioscience
2 Citations for PAC 1
Citations are publications that use Tocris products. Selected citations for PAC 1 include:
Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571
Yosefzon et al (2018) Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell 70 573 PMID: 29775577
Do you know of a great paper that uses PAC 1 from Tocris? Please let us know.
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