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Submit ReviewHemopressin (human, mouse)
Description: Selective CB1 inverse agonist
Biological Activity for Hemopressin (human, mouse)
Hemopressin (human, mouse) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
Technical Data for Hemopressin (human, mouse)
| M. Wt | 1054.26 |
| Formula | C50H79N13O12 |
| Sequence | PVNFKLLSH |
| Storage | Store at -20°C |
| CAS Number | 1314035-51-2 |
| PubChem ID | 90488877 |
| InChI Key | JEXQOFXDPAGOQL-TZFLQVIRSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Hemopressin (human, mouse)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Hemopressin (human, mouse)
References for Hemopressin (human, mouse)
References are publications that support the biological activity of the product.
Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972
Blais et al (2005) Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 26 1317 PMID: 16042973
Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA 104 20588
If you know of a relevant reference for Hemopressin (human, mouse), please let us know.
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Keywords: Hemopressin (human, mouse), Hemopressin (human, mouse) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Receptors, Other, /, Activators, 3791, Tocris Bioscience
1 Citation for Hemopressin (human, mouse)
Citations are publications that use Tocris products. Selected citations for Hemopressin (human, mouse) include:
Jimenez-Blasco et al (2020) Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature 583 603 PMID: 32641832
Do you know of a great paper that uses Hemopressin (human, mouse) from Tocris? Please let us know.
Reviews for Hemopressin (human, mouse)
Average Rating: 5 (Based on 1 Review.)
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Our experiments looked into CB1 receptors using Hemopressin.
By
Anonymous on 02/19/2019
Species: Human
The endocannabinoid system consists of at least two cannabinoid receptors, CB1 and CB2. Our experiments looked into CB1 receptors using Hemopressin and they were cloned.
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